Lucas Cano, (Machete) an ex-bodyguard for the Mexican President, bored of his life style, retires to an isolated small town in Mexico, in hope of finding harmony. But things do not work out for him the way he wants them to. First, he must face several drug dealers who smuggle illegitimate immigrants into the United States, forcing them to smuggle drugs. Then, Machete finds out that his old Vietnam buddy, who now works for the CIA in Arizona, has been assigned to take into custody Machete, and take him back to the US for some old accusations. Machete's health is fading speedily. He is continuously bleeding internally, but he won't discontinue drinking and smoking. Panchito is a little boy Machete met in a street fight, and the little boy, claiming not to have any relatives, decides to hang out with Machete and tries to help him transform his life style. Machete does not know that a higher organization is watching out for him. Panchito is an guardian angel sent by God to save his body and soul. Esperanza (Pelancho) meets Machete when one of the drug dealers tries to rape her. Esperanza without delay feels a link among them, but can't tell what it is. Machete gets the similar sensation and starts to inspect who the girl is and where she comes from. Esperanza's mother, persuaded by the local priest to tell Esperanza the connection linking her and Machete, confesses to her but it is too delayed. Machete has been shot by Ruidoso and is on its last legs.
